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Archive for December, 2008
What are flavonoids
Steve P Smith asked:

There’s now good evidence that it’s not just in fruits and vegetables that health promoting anti-oxidant flavonoids are to be found. These powerful compounds have also been identified in tea, particularly green tea, red wine, beer and even chocolate. So if you’ve ever suspected that many of those who advocate healthy diets are motivated more by denying you your little pleasures than a genuine interest in your well being, now may be the time to take a little revenge.

Flavonoids occur widely in fruits and vegetables and their principal function appears to be to protect these plants from disease and the damage which may be caused to them by extremes of light or heat. It has long been suspected, however, that the well established health protecting and curative properties of the many plants commonly used in folk remedies for humans may also be due to flavonoids. And there is now abundant evidence to support the idea that certain flavonoids, particularly those of the polyphenol type, possess potent anti-inflammatory and anti-oxidant properties.

Two of the biggest premature killers in the affluent Western world, as well as major causes of disability and early loss of independence, are stroke and heart disease. Both frequently follow on the development of the cardiovascular disease, atherosclerosis, otherwise known as hardening of the arteries, and it is known that the oxidation of low density lipids (LDL), the blood fats known as “bad cholesterol”, is one of the major causes of this condition. The prevention of LDL oxidation is one of the key functions of vitamin E, the body’s most important fat-soluble anti-oxidant, but anti-oxidant flavonoids are also known to play a role.

Consistent research findings confirming this benefit of flavonoid anti-oxidants have led successive governments and health agencies to urge the public to consume at least five daily servings of fresh fruits and vegetables, and the evidence indeed suggests that such high flavonoid diets are linked to a reduced risk of heart disease and perhaps even some cancers.

But it’s not just the flavonoids in fruits and vegetables that may have these effects. Much attention, for example, has recently been paid to the so-called “French Paradox”, whereby France boasts a surprisingly low rate of heart disease and related conditions, given the preponderance of saturated animal fat in its national diet. There has been much speculation that the low rate of this disease, by the standards of advanced Western nations, may be linked with relatively high consumption of red wine, and analysis of the anti-oxidants in this drink, also found in red grape juice, suggests that the theory may have some substance.

And at least one major study has suggested that the incidence of stroke is substantially reduced in older people, otherwise a very high risk group for this illness, who regularly drink substantial quantities of tea, which is also rich in anti-oxidant polyphenols, but whose diet tends to be low in fresh fruits and vegetables.

As well as red wine and tea, there is now also evidence that anti-oxidant flavonoids may be found in beer and even chocolate. But in fact this is not as surprising as it may at first appear. The coca beans which are the primary ingredient of chocolate are a good source of polyphenols, and were known to ancient civilisations for their medicinal properties. Broadly speaking, the darker the chocolate the richer it will be in the particular flavonoids derived from the beans, which are powerful anti-oxidant agents not commonly found elsewhere.

The latest research seems to offer good evidence that the flavonoids particular to dark chocolate (procyanidins) may have a useful role in helping to prevent the oxidation of the LDL, “bad cholesterol”, which is, as noted above, a key precursor of serious cardiovascular disease. Procyanidins also appear to work closely with vitamin E, the body’s most important fat-soluble anti-oxidant, sparing the vitamin to work more effectively, and may also help to prevent excessive clotting or “stickiness” of the blood. Procyanidins are readily absorbed by the body following the consumption of dark chocolate and appear to have a significant overall anti-oxidant effect in the cardiovascular system.

But of course it’s not all good news. You’ll be only too well aware of the health reasons why it would be unwise to rely on tea, red wine, beer or chocolate as your principal sources of dietary anti-oxidant flavonoids. De-caffeinated teas are available, however, and dark chocolate is relatively low in sugar and fat; whilst all the evidence suggests that moderate consumption of alcohol may protect against a variety of conditions, including heart disease. Red wine, in particular, is rich in the anti-oxidant flavonoids which appear to offer significantly enhanced protection.

As always, the key is balance; and in the context of an otherwise healthy diet, particularly one rich in fruit and vegetables, there is no reason why these highly enjoyable luxury foods and beverages should not make an important contribution to your overall level of anti-oxidant intake.

What are antioxidants
Dr. Paul Gross asked:


Meet the “New-trients”

Today’s consumers are witnessing a new era in how foods are identified. New nutrients, not commonly understood for their health benefits, seem to be popping up on our grocer’s shelves every day. Omega fatty acids, newly defined sources of dietary fiber, and antioxidant phytochemicals are examples of healthful plant elements that are creeping into public media reports and water-cooler debates.

Laboratory and preliminary human clinical studies are revealing anti-disease properties of these “nutrients.” Extensive food and medical research underway presently will eventually translate the chemical properties into consumer understanding and terminology that we’ll grasp and use in everyday conversation.

With such potential significance to public health, the consumer education process should begin now in a way that people, from teenagers to grandparents, can readily understand antioxidants as easily as we now understand calories, carbohydrates, fat percentage, and vitamin C.

The scientific and regulatory bodies for food labeling have a great challenge ahead of them.

There are thousands of plant food sources with suspected health benefits with complicated chemical names that are unfamiliar and can be intimidating. The challenge at hand is to decipher this blizzard of names and to promote better nutrition for our families and for ourselves.

Why Antioxidants?

The beneficial antioxidant chemicals that we get from colorful plant foods represent our best defense against threatening oxidants. While oxidative stress is a normal part of cellular metabolism that occurs even in healthy people, left unchecked, it can lead to damage that accumulates with age.

Normally, oxidative species or “free radicals” are neutralized by antioxidant enzymes and food-derived antioxidants. However, the following circumstances can cause an imbalanced oxidant-antioxidant relationship that allows oxidative stress to go unopposed.

• Contamination by environmental conditions like pollution, radiation, cigarette smoke and herbicides

• Normal aging

• Poor diets that lack essential nutrients and phytochemicals

The result of this imbalance is cell and tissue damage that could lead to diseases like:

• Cancer

• Hypertension

• Diabetes

• Chronic inflammation

• Neuronal degeneration like Alzheimer’s disease

The Color Code for Antioxidants

Over the past five years, we have begun a valuable process for recognizing plant food antioxidant qualities by groupings of color—The Color Code, as written in two books entitled The Color Code and What Color is Your Diet? (publication information below).

The following is a summary of those color guides for antioxidants, and an example of how we can begin to classify and categorize the different antioxidants into the food color code.

Summary of the Color Code

This is a general scheme of example foods that can fit into each color class. Keep in mind that there are no firm lines between the classes, which allows for overlap.

1. Red – tomato, pink grapefruit, watermelon

2. Blue/Red/Purple/Black (BRPB) – blueberry, cherry, prune, blackberry

3. Orange/Yellow – carrot, pumpkin, orange, papaya

4. Green – broccoli, kale, spinach, pea

5. White – garlic, onion, cabbage, turnip

6. Brown/Gray – spices, nuts, seeds, endogenous sources

How to Apply the Color Code

Here’s a general breakdown of the color groups that have food chemicals with antioxidant qualities:

1.Enzymes (Brown/Gray)

A protein substance with a name ending in “ase”, enzymes stimulate biochemical reactions in living cells and help form new compounds that, in this case, would serve antioxidant functions.

Members of this enzyme class of antioxidants include:

• Superoxide dismutase

• Catalases

• Reductases

• Peroxidases

• Transferases

2.Vitamins (Brown/Gray)

Most consumers would already recognize the three main antioxidant vitamins—A, C and E—that are derived from food and supplements common to the public. Vitamins A and E are fat-soluble, providing antioxidant protection in cell structures like the outer membrane and inner nuclear organelles. Vitamin C dissolves readily in body water compartments, so it is well distributed in the body. Of particular note is the important role of vitamin C in protecting vitamins A and E from damaging oxidative free radicals.

3.Phenolics (BRPB)

With more than 8,000 individual chemicals that serve plants as pigments, the phenolics (also called phenols or polyphenols) are water-soluble acids that not only give plants colors, but also differentiate scents, tastes, and bitterness. The large class of phenolics (called flavonoids) is often mentioned in current public media. Quercetin, kaempferol and peonidin are examples of flavonoids that have been in the news recently.

4.Carotenoids (Orange/Yellow, Red)

A fat-soluble group of more than 600 individual chemicals, the carotenoids (e.g., beta-carotene, lycopene, lutein and zeaxanthin “zee-a-zan-thin”) are especially powerful antioxidants. Due to their chemical structure, they are an excellent source of electrons that are aggressively sought by oxidative free radicals. A carotenoid molecule donates electrons to a free radical, sacrificing itself in antioxidant defense. Terpenes and xanthophylls are included in this class.

5.Hormones (Brown/Gray)

A growing field of medical research is identifying normal hormones typically described with cell-to-cell messaging roles in the body as having antioxidant functions. Presently only a few hormones have this identified property such as melatonin, estradiol and insulin, but future research will likely unravel similar functions for the dozens of hormones known in human physiology.

6.Minerals (All colors)

Minerals have elements that enable enzyme activity. Selenium, zinc, manganese, magnesium and copper are minerals involved in hundreds of antioxidant roles in the body.

7.Glutathione (Brown/Gray)

Probably the human body’s single most important native antioxidant, glutathione is a water-soluble molecule synthesized from food-derived amino acids. It also depends on lipoic acid (below) for synthesis.

8.Lipid effectors (Orange/Yellow)

Lipoic acid is perhaps the “perfect” antioxidant because it is a small powerful molecule that dissolves readily both in fatty layers of cells and in water – the only antioxidant to do this. Other lipid oriented antioxidants include omega fatty acids, tocopherols (like vitamin E), phytosterols, perillyl alcohol and essential oils such as limonene.

9.Saponins, steroids and stilbenes (Green, BRPB)

Related in this discussion only by their common first letter “s”, this group has established antioxidant functions and includes some well-known chemicals such as resveratrol (a stilbene of red wine and dark grapes), brassinosteroid (the growth regulator of plants) and saponin (the waxy covering on plant leaves).

10.Sulfur-containing chemicals (Green, White)

Including organosulfides, tri and diallyl sulfides and sulforaphane, this group from plants like broccoli and cabbage has been shown to have properties affecting antioxidant enzyme activity, inflammatory mediators and tumor growth.

Proposing an Antioxidant Nomenclature

Just as vitamins have been given a nominal identity (Vitamin A, B, C…etc) so too should we refer to antioxidants. This is a new system not yet formally proposed to any regulatory authority or scientific body. Classification of antioxidants must undergo the scrutiny, revision and adoption by scientists, industry and government to be acceptable for food label use in the public.

Here is the proposed breakdown:

1. Antioxidant C – carotenoids

2. Antioxidant E – enzymes

3. Antioxidant G – glutathione

4. Antioxidant H – hormones

5. Antioxidant L – lipid-associated chemicals

6. Antioxidant M – minerals

7. Antioxidant P – phenolics

8. Antioxidant S – saponins, steroids, stilbenes, sulfurs

9. Antioxidant V – vitamins

Over time, the public must feel these proposed antioxidant classes are informative and practical for understanding antioxidants and choosing preferred foods. Time will tell, but this list gives us a simple working structure to get a handle on naming antioxidants.

Reading

* Heber D. What Color Is Your Diet? HarperCollins, New York, 2001.

* Joseph JA, Nadeau DA, Underwood A. The Color Code, Hyperion, New York, 2002.

* Lee J, Koo N, Min DB. Reactive oxygen species, aging, and antioxidative nutraceuticals. Compreh. Rev. Food Sci. Food Safety 3:21-33, 2004.

Copyright 2006 Berry Health Inc.



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